Novel Properties of a Mouse γ-Aminobutyric Acid Transporter (GAT4)
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چکیده
منابع مشابه
GATMD: γ-Aminobutyric Acid Transporter Mutagenesis Database
Since the cloning of the first γ-aminobutyric acid (GABA) transporter (GAT1; SLC6A1) from rat brain in 1990, more than 50 published studies have provided structure-function information on investigator-designed rat and mouse GAT1 mutants. To date, more than 200 of 599 GAT1 residues have been subjected to mutagenesis experiments by substitution with different amino acids, and the resulting transp...
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gamma-Aminobutyric acid (GABA) transporters (GATs) play an important role in inhibitory neurotransmission by clearing synaptically released GABA and by maintaining low resting levels of GABA in synaptic and extrasynaptic regions. In certain brain regions, vesicular zinc is colocalized and coreleased with glutamate and modulates the behavior of a number of channels, receptors, and transporters. ...
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ژورنال
عنوان ژورنال: Journal of Membrane Biology
سال: 2005
ISSN: 0022-2631,1432-1424
DOI: 10.1007/s00232-004-0732-5